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Zebrafish Bioassay for Screening Therapeutic Candidates Based on Melanotrophic Activity by Ted I. Hong; Kyu-Seok Hwang; Tae-Ik Choi; Gunnar Kleinau; Patrick Scheerer; Jeong Kyu Bang; Seung-Hyun Jung; Cheol-Hee Kim is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Zebrafish Bioassay for Screening Therapeutic Candidates Based on Melanotrophic Activity about?
In this study, we used the zebrafish animal model to establish a bioassay by which physiological efficacy differential of alpha-melanocyte-stimulating hormone (α-MSH) analogues could be measured by melanosome dispersion in zebrafish larvae. Brain-skin connection research has purported the interconnectedness between the nervous system and skin physiology. Accordingly, the neuropeptide α-MSH is a key regulator in several physiological processes, such as skin pigmentation in fish. In mammals, α-MSH has been found to regulate motivated behavior, appetite, and emotion, including stimulation of satiety and anxiety. Several clinical and animal model studies of autism spectrum disorder (ASD) have already demonstrated the effectiveness of α-MSH in restoring the social deficits of autism. Therefore, we sought to analyze the effect of synthetic and naturally-occurring α-MSH variants amongst different species. Our results showed that unique α-MSH derivatives from several fish species produced differential effects on the degree of melanophore dispersion. Using α-MSH human form as a standard, we could identify derivatives that induced greater physiological effects; particularly, the synthetic an
Who reads Zebrafish Bioassay for Screening Therapeutic Candidates Based on Melanotrophic Activity?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ted I. Hong; Kyu-Seok Hwang; Tae-Ik Choi; Gunnar Kleinau; Patrick Scheerer; Jeong Kyu Bang; Seung-Hyun Jung; Cheol-Hee Kim
- Publisher
- MDPI AG
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)