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Dendrobium huoshanense in the treatment of ulcerative colitis: Network pharmacology and experimental validation by Liang Yao; Jing Fang; Junwei Zhao; Jiao Yu; Xiaoqian Zhang; Weidong Chen; Lan Han; Daiyin Peng; Yunna Chen is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Dendrobium huoshanense in the treatment of ulcerative colitis: Network pharmacology and experimental validation about?

Ethnopharmacological relevance: Dendrobium huoshanense C. Z. Tang et S. J. Cheng (DH) is a traditional medicinal herb with a long history of medicinal use. DH has been recorded as protecting the gastrointestinal function. Modern pharmacology research shows that DH regulates intestinal flora, intestinal mucosal immunity, gastrointestinal peristalsis and secretion of digestive juices. At the same time, some studies have shown that DH has a good therapeutic effect on ulcerative colitis, but its mechanism of action has not been fully elucidated. ## Aims of this study: To investigate the mechanism and effect of Dendrobium huoshanense C. Z. Tang et S. J. Cheng (DH) in the treatment of ulcerative colitis (UC) by combining network pharmacology and in vivo experimental validation. Methods: A network pharmacology approach was used to perform component screening, target prediction, PPI network interaction analysis, GO and KEGG enrichment analysis to initially predict the mechanism of DH treatment for UC. Then, the mechanism was validated with the UC mouse model induced by 3% DSS. Results: Based on the network pharmacological analysis, a comprehensive of 101 active components were identified,

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Author

Liang Yao; Jing Fang; Junwei Zhao; Jiao Yu; Xiaoqian Zhang; Weidong Chen; Lan Han; Daiyin Peng; Yunna Chen

Publisher

Elsevier BV

Published

2024

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)