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Levels of Interleukin-15-Expressing Blood Mononuclear Cells Are Elevated in Multiple Sclerosis by Pashenkov; Mustafa; Kivisäkk; Link is a Immunology and Microbiology article available to read on EtoBox.

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Interleukin‐15 (IL‐15) is a novel IL‐2‐like cytokine expressed by cells of the monocyte/macrophage and epithelial lineages. Cytokines might be involved in the pathogenesis of multiple sclerosis (MS). Using immunocytochemistry, we analysed spontaneous expression of IL‐15 by peripheral blood (PB) and cerebrospinal fluid (CSF) mononuclear cells (MNC) from patients with MS, other neurological diseases (OND) and healthy controls. IL‐15‐ positive peripheral blood mononuclear cells (PBMNC) were elevated in patients with MS compared to healthy controls (__P <__0.05). The elevation of IL‐15‐ positive PBMNC was restricted to patients with chronic progressive MS and not observed in patients studied during the relapsing‐remitting phase of MS. The numbers of IL‐15‐ expressing PBMNC correlated with the duration and disability of MS (__r__= 0.45, __P__< 0.001, and __r__= 0.39, __P__< 0.01, respectively). IL‐15 was undetectable in CSF MNC, and ELISA showed low CSF levels of IL‐15 in occasional patients with MS and OND. IL‐15 is a potent growth factor for γδ T cells, but there was no correlation between IL‐15 expression by PBMNC and percentage of γδ T cells in blood from the MS patients. Together,

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Author

Pashenkov; Mustafa; Kivisäkk; Link

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0300-9475)

Published

1999

Language

EN

Field

Immunology and Microbiology (Life Sciences)