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The role of intrahepatic lymphocytes in mediating protective immunity induced by attenuated Plasmodium berghei sporozoites by Urszula Krzych; Robert Schwenk; Mimi Guebre-Xabier; Peifang Sun; Dupeh Palmer; Katherine White; Isaac Chalom is a Immunology and Microbiology article available to read on EtoBox.
What is The role of intrahepatic lymphocytes in mediating protective immunity induced by attenuated Plasmodium berghei sporozoites about?
**Summary:** Exposure to irradiated __Plasmodium__ sporozoites (g‐spz) results in protection against malaria. Like infectious spz, g‐spz colonize hepatocytes to undergo maturation. Disruption of liver stage development prevents the generation of protection, which appears, therefore, to depend on liver stage antigens. Although some mechanisms of protection have been identified, they do not include a role for intrahepatic mononuclear cells (IHMC). We demonstrated that __P. berghei__ g‐spz‐immune murine IHMC adoptively transfer protection to naive recipients. Characterization of intrahepatic CD4+ T cells revealed an immediate, albeit transient, response to g‐spz, while the response of CD8+ T cells is delayed until acquisition of protection. It is presumed that activated CD8+ T cells home to the liver to die; g‐spz‐induced CD8+CD45RBloCD44hi T cells, however, persist in the liver, but not the spleen, during protracted protection. The association between CD8+CD45RBloCD44hi T cells and protection has been verified using MHC class I and CD1 knockout mice and mice with disrupted liver stage parasites. Based on kinetic studies, we propose that interferon‐g, presumably released by intrahepat
Who reads The role of intrahepatic lymphocytes in mediating protective immunity induced by attenuated Plasmodium berghei sporozoites?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Urszula Krzych; Robert Schwenk; Mimi Guebre-Xabier; Peifang Sun; Dupeh Palmer; Katherine White; Isaac Chalom
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0105-2896)
- Published
- 2000
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)