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Glutamate Transporter Expression in Astrocytes of the Rat Dentate Gyrus Following Lesion of the Entorhinal Cortex by C. Hein; E. Horváth; P. Kugler is a Neuroscience article available to read on EtoBox.

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## Abstract The glutamate transporters GLT‐1 and GLAST localized in astrocytes are essential in limiting transmitter signalling and restricting harmful receptor overstimulation. To show changes in the expression of both transporters following lesion of the entorhinal cortex (and degeneration of the glutamatergic tractus perforans), quantitative microscopic __in situ__ hybridization (ISH) using alkaline‐phosphatase‐labelled oligonucleotide probes was applied to the outer molecular layer of the hippocampal dentate gyrus of rats (termination field of the tractus perforans). Four groups of rats were studied: sham‐operated controls, and animals 3, 14 and 60 days following unilateral electrolytic lesion of the entorhinal cortex. The postlesional shrinkage of the terminal field of the perforant path, ipsilateral to the lesion side, was determined and considered in the evaluation of quantitative ISH data. Statistical analysis revealed that ipsilateral to the lesion side there was a significant decrease of the GLT‐1 mRNA at every postlesional time‐point and of the GLAST mRNA at 14 and 60 days postlesion. The maximal decrease was ≈ 45% for GLT‐1 and ≈ 35% for GLAST. In the terminal field of

Who reads Glutamate Transporter Expression in Astrocytes of the Rat Dentate Gyrus Following Lesion of the Entorhinal Cortex?

Author

C. Hein; E. Horváth; P. Kugler

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

2001

Language

EN

Field

Neuroscience (Life Sciences)