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Eicosapentaenoic Acid Stimulates the Expression of Myelin Proteins in Rat Brain by Serafina Salvati; Francesco Natali; Lucilla Attorri; Rita Di Benedetto; Fabiana Leonardi; Antonella Di Biase; Federica Ferri; Stefano Fortuna; Paola Lorenzini; Massimo Sanchez; Laura Ricceri; Luigi Vitelli is a Neuroscience article available to read on EtoBox.
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## Abstract We have previously demonstrated that, in C6 glioma cells, eicosapentaenoic acid (EPA) stimulates the expression of proteolipid protein (PLP) via cAMP‐mediated pathways. In this study, we investigated whether n‐3 polyunsaturated fatty acids can affect myelinogenesis in vivo. A single dose of either EPA or docosahexaenoic acid (DHA) was injected intracerebroventricularly into 2‐day‐old rats, which were then killed after 3 days post‐injection (p.i.). Total RNA was isolated from the medulla, cerebellum, and cortex, and the expression of myelin‐specific mRNAs was analyzed by real‐time PCR. The levels of PLP, myelin basic protein, and myelin oligodendrocyte protein mRNAs increased in nearly all brain regions of DHA‐ and EPA‐treated animals, but the effect was more pronounced in EPA‐treated rats. The enhancement in PLP transcript levels was followed by an increase in PLP translation in EPA‐treated rats. A further indicator of accelerated myelination was the increase in 2′‐3′‐cyclic nucleotide 3′‐phosphodiesterase (CNPase) protein levels. In EPA‐treated rats, the increased expression of myelin genes coincided with a decrease of cAMP‐response element‐binding protein (CREB)‐DNA b
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- Author
- Serafina Salvati; Francesco Natali; Lucilla Attorri; Rita Di Benedetto; Fabiana Leonardi; Antonella Di Biase; Federica Ferri; Stefano Fortuna; Paola Lorenzini; Massimo Sanchez; Laura Ricceri; Luigi Vitelli
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2007
- Language
- EN
- Field
- Neuroscience (Life Sciences)