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Myositis ossificans-like soft tissue aneurysmal bone cyst: a clinical, radiological, and pathological study of seven cases with COL1A1-USP6 fusion and a novel ANGPTL2-USP6 fusion by Lingxin Zhang; Sinchun Hwang; Ryma Benayed; Guo Gord Zhu; Kerry A. Mullaney; Kelly M. Rios; Purvil Y. Sukhadia; Narasimhan Agaram; Yanming Zhang; Julia A. Bridge; John H. Healey; Edward A. Athanasian; Meera Hameed is a Medicine article available to read on EtoBox.

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Herein we described the clinical, radiological, histological, and molecular characteristics of seven soft tissue aneurysmal bone cysts (STABCs) diagnosed and managed at a tertiary cancer center and to elucidate their relationship with myositis ossificans (MO). All cases had established imaging and histopathological diagnosis of STABC and were subject to fluorescence in situ hybridization (FISH) for USP6 rearrangement and Archer® FusionPlex® targeted RNA sequencing (RNASeq) analysis to identify the fusion partner. A thorough literature review of STABC and MO was conducted. The patients presented with painful masses unpreceded by trauma, occurring most commonly in the deep soft tissue of the thigh/gluteus (4/7), and also in the supraclavicular region, the axilla, and the hand. On imaging, the lesions were frequently associated with peripheral calcification on conventional radiographs and CT (6/7), cystic components on ultrasound, as well as perilesional edema (7/7) and fluid levels (3/7) on MRI. Bone scan (1/1) showed intense radiotracer uptake. Histologically, 6/7 cases demonstrated zonal arrangements reminiscent of MO. USP6 rearrangement was found in all seven cases by FISH and/or

Who reads Myositis ossificans-like soft tissue aneurysmal bone cyst: a clinical, radiological, and pathological study of seven cases with COL1A1-USP6 fusion and a novel ANGPTL2-USP6 fusion?

Author

Lingxin Zhang; Sinchun Hwang; Ryma Benayed; Guo Gord Zhu; Kerry A. Mullaney; Kelly M. Rios; Purvil Y. Sukhadia; Narasimhan Agaram; Yanming Zhang; Julia A. Bridge; John H. Healey; Edward A. Athanasian; Meera Hameed

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Medicine (Health Sciences)