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Approach for in vivo delivery of CRISPR/Cas system: a recent update and future prospect by Yu-Fan Chuang; Andrew J. Phipps; Fan-Li Lin; Valerie Hecht; Alex W. Hewitt; Peng-Yuan Wang; Guei-Sheung Liu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Approach for in vivo delivery of CRISPR/Cas system: a recent update and future prospect about?

The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system provides a groundbreaking genetic technology that allows scientists to modify genes by targeting specific genomic sites. Due to the relative simplicity and versatility of the CRISPR/Cas system, it has been extensively applied in human genetic research as well as in agricultural applications, such as improving crops. Since the gene editing activity of the CRISPR/Cas system largely depends on the efficiency of introducing the system into cells or tissues, an efficient and specific delivery system is critical for applying CRISPR/Cas technology. However, there are still some hurdles remaining for the translatability of CRISPR/Cas system. In this review, we summarized the approaches used for the delivery of the CRISPR/Cas system in mammals, plants, and aquacultures. We further discussed the aspects of delivery that can be improved to elevate the potential for CRISPR/ Cas translatability Keywords CRISPR/Cas • Gene editing • Gene delivery • Gene therapy Cellular and Molecular Life Sciences

Who reads Approach for in vivo delivery of CRISPR/Cas system: a recent update and future prospect?

Author

Yu-Fan Chuang; Andrew J. Phipps; Fan-Li Lin; Valerie Hecht; Alex W. Hewitt; Peng-Yuan Wang; Guei-Sheung Liu

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)