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Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease by Irena Rektorova; Jennifer Barrett; Michal Mikl; Ivan Rektor; Tomas Paus is a Medicine article available to read on EtoBox.

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## Abstract Parkinson's disease (PD) affects speech, including respiration, phonation, and articulation. We measured the blood oxygen level‐dependent (BOLD) response to overt sentence reading in: (1) 9 treated female patients with mild to moderate PD (age; mean 66.0 ± 11.6 years, mean levodopa equivalent 583.3 ± 397.9 mg) and (2) 8 age‐matched healthy female controls (age; mean 62.2 years ± 12.3). Speech was recorded in the scanner to assess which brain regions underlie variations in the initiation and paralinguistic aspects (e.g., pitch, loudness, and rate) of speech production in the two groups. There were no differences in paralinguistic aspects of speech except for speech loudness; it was lower in PD patients compared with that in controls, when age was used as a covariate. In both groups, we observed increases in the BOLD response (reading‐baseline) in brain regions involved in speech production and perception. In PD patients, as compared with controls, we found significantly higher BOLD signal in the right primary orofacial sensorimotor cortex and more robust correlations between the measured speech parameters and the BOLD response to reading, particularly, in the left primar

Who reads Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease?

Author

Irena Rektorova; Jennifer Barrett; Michal Mikl; Ivan Rektor; Tomas Paus

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

2007

Language

EN

Field

Medicine (Health Sciences)