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Can I read In vitro genotoxicity assessment and comparison of cerium (IV) oxide micro- and nanoparticles on EtoBox?
In vitro genotoxicity assessment and comparison of cerium (IV) oxide micro- and nanoparticles by Arslan, Kader; Akbaba, Giray BuÄra is a Environmental Science article available to read on EtoBox.
What is In vitro genotoxicity assessment and comparison of cerium (IV) oxide micro- and nanoparticles about?
Cerium (IV) oxide (CeO2), which is used as a biomaterial, has wide application in areas such as the biomedical, glass polishing, electronic, automotive, and pharmacology industries. Comparing with the literature, in this study, the genotoxic effects of cerium (IV) oxide microparticles (COMPs) and cerium (IV) oxide nanoparticles (CONPs) were investigated for the first time in human peripheral blood cultures at concentrations of 0.78, 1.56, 3.125, 6.25, 12.5, 25, and 50 ppm for 72 h under in vitro conditions. Particle sizes of COMPs and CONPs were determined using scanning electron microscopic analysis. Micronucleus and chromosome aberration tests were used to determine the genotoxicity of COMPs and CONPs. The average particle sizes of COMPs and CONPs were approximately 148.25 and 25.30 nm, respectively. It was determined that CeO2 particles in both micro and nano sizes were toxic at all concentrations compared to the negative control group (distilled water). Importantly, COMPs and CONPs were genotoxic even at the lowest concentration (0.78 ppm). Comparing particle sizes, the data indicated that COMPs were more toxic than CONPs. The results suggest that genotoxicity of COMPs and CONP
Who reads In vitro genotoxicity assessment and comparison of cerium (IV) oxide micro- and nanoparticles?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Arslan, Kader; Akbaba, Giray BuÄra
- Publisher
- SAGE Publications (ISSN 0748-2337)
- Published
- 2020
- Language
- EN
- Field
- Environmental Science (Physical Sciences)