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Reduced Intensity and Non-myeloablative Allogeneic Stem Cell Transplantation in Children and Adolescents with Malignant and Non-malignant Diseases by Prakash Satwani; Erin Morris; M. Brigid Bradley; Monica Bhatia; Carmella van de Ven; Mitchell S. Cairo is a Medicine article available to read on EtoBox.

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## Abstract Allogeneic hematopoietic stem cell transplant (AlloSCT) from related or unrelated histocompatible donors has been well established as potentially curative therapy for children and adolescents with selected malignant and non‐malignant diseases. In the malignant setting non‐myeloablative (NMA)/reduced intensity (RI)‐AlloSCT eradicates malignant cells through a graft versus malignancy effect provided by alloreactive donor T‐lymphocytes and/or natural killer cells. In patients with non‐malignant diseases NMA/RI AlloSCT provides enough immunosuppression to promote engraftment and correct underlying genetic defects. In children, myeloablative AlloSCT is not only associated with acute short‐term toxicities but also long‐term late complications such as growth retardation, infertility, and secondary malignancies. NMA/RI‐AlloSCT in children may be associated with reduction in use of blood products, risk of infections, transplant‐related mortality, and length of hospitalization. Despite the success of RI‐AlloSCT in adults, large prospective and/or randomized multicenter studies are necessary in children and adolescent recipients to define the appropriate patient population, optima

Who reads Reduced Intensity and Non-myeloablative Allogeneic Stem Cell Transplantation in Children and Adolescents with Malignant and Non-malignant Diseases?

Author

Prakash Satwani; Erin Morris; M. Brigid Bradley; Monica Bhatia; Carmella van de Ven; Mitchell S. Cairo

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2007

Language

EN

Field

Medicine (Health Sciences)