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Can I read The Impact of Stress on Immune Systems and Its Relevance to Mental Illness on EtoBox?
The Impact of Stress on Immune Systems and Its Relevance to Mental Illness by Yuka Ishikawa; Tomoyuki Furuyashiki is a Neuroscience article available to read on EtoBox.
What is The Impact of Stress on Immune Systems and Its Relevance to Mental Illness about?
Stress due to adverse and demanding conditions alters immune functions. How innate and adaptive immune systems respond to stress and affect neural processes remains unclear. Rodent studies have demonstrated crucial roles of stress-induced immune responses for depressive- and anxiety-like behaviors. In the periphery, stress evokes the mobilization of neutrophils and monocytes to the circulation via sympathetic nerves and glucocorticoids. These myeloid cells are thought to promote depressive- and anxiety-like behaviors by infiltrating the brain's perivascular space, releasing cytokines, and affecting vascular endothelial functions. In the brain, stress activates microglia via innate immune receptors TLR2/4. The activated microglia in the medial prefrontal cortex secrete cytokines and alter neuronal morphology and activity in their vicinity. In subcortical brain areas, prostaglandin (PG) E released from the activated microglia attenuates the dopaminergic projection to the medial prefrontal cortex via PGE receptor EP1. These multiple actions of microglia promote depressive-like behavior in concert. These rodent findings may be translatable to depression that clinical studies have assoc
Who reads The Impact of Stress on Immune Systems and Its Relevance to Mental Illness?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Yuka Ishikawa; Tomoyuki Furuyashiki
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Neuroscience (Life Sciences)