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Diagnoisis of Neural Crest Tumors by Reversed-phase High-performance Liquid Chromatographic Determination of Urinary Catecholamine Metabolites by Anté M. Krstulovic; Mona Zakaria; Klaus Lohse; Laura Bertani-Dziedzic is a Chemistry article available to read on EtoBox.
What is Diagnoisis of Neural Crest Tumors by Reversed-phase High-performance Liquid Chromatographic Determination of Urinary Catecholamine Metabolites about?
Aberrations in the metabolic pathways of catecholamines in patients with neural crest tumors result in characteristic urinary excretion patterns of their catab-o&s. Tumors such as pheochromocytoma, neuroblastoma and ganglioneuroma usually defy clinical diagnosis because of their rarity, small size, intraatiominal position and clinical symptoms similar to those of essential hypertension. Quantitative determination of catecholamiue metabolites such as vauillylmandelic acid (VMA) and 3-methoxy4hydroxyphenylethyleneglycol (MHPG) offers possibilities for reliable confirmation of diagnosis. However, previous techniques for the assessment of catabolite levels suffered from inadequate sensitivity, reproducibility or specikity, which seriously diminished their usefulness as biochemical determinants in the prognosis of these life-threatening tumors. Reported in this paper is the analysis of urinary levels of VMA and MHPG using reversed-phase high-performance liquid chromatography with electrochemical and spectrophotometric detection. We present the excretion patterns showing these metabolites iu 15 control subjects, 15 patients with pheochromocytoma and 5 patients with neuroblastoma. INTEtOD
Who reads Diagnoisis of Neural Crest Tumors by Reversed-phase High-performance Liquid Chromatographic Determination of Urinary Catecholamine Metabolites?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Anté M. Krstulovic; Mona Zakaria; Klaus Lohse; Laura Bertani-Dziedzic
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)
- Published
- 1979
- Language
- EN
- Field
- Chemistry (Physical Sciences)
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