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Can I read Glial Cells Assemble Hyaluronan-based Pericellular Matrices in Vitro on EtoBox?
Glial Cells Assemble Hyaluronan-based Pericellular Matrices in Vitro by Michael Maleski; Susan Hockfield is a Neuroscience article available to read on EtoBox.
What is Glial Cells Assemble Hyaluronan-based Pericellular Matrices in Vitro about?
The extracellular matrix (ECM) of the brain contains hyaluronan and proteoglycans, as does the ECM of cartilage. Aggrecan, the major proteoglycan of cartilage, forms large aggregates with hyaluronan, which then associate with the chondrocyte cell surface through an interaction with surface hyaluronan binding proteins. In culture, chondrocytes elaborate hyaluronan-proteoglycan aggregates, which form large hydrated pericellular matrices (PCMs) that can be visualized by a particle exclusion assay (Knudson and Toole: Dev Biol 112:308, 1985). It has recently been demonstrated that embryonic glial cells can also elaborate PCMs in culture (Deyst and Toole: Dev Brain Res 28:351, 1995). We demonstrate here that different classes of glial cells elaborate different types of endogenous PCMs in culture. Less differentiated glial cells, as evidenced by their immunoreactivity for nestin, elaborate larger endogenously produced PCMs than differentiated astrocytes, as defined by immunoreactivity for GFAP. This in vitro result may be a reflection of the larger volume of extracellular space present in the embryonic than in the mature brain. We show further that glial cells can incorporate cartilage ag
Who reads Glial Cells Assemble Hyaluronan-based Pericellular Matrices in Vitro?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Michael Maleski; Susan Hockfield
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)
- Published
- 1997
- Language
- EN
- Field
- Neuroscience (Life Sciences)