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Can I read Cholinergic modulation of angiogenesis: Role of the 7 nicotinic acetylcholine receptor on EtoBox?
Cholinergic modulation of angiogenesis: Role of the 7 nicotinic acetylcholine receptor by Jenny C.F. Wu; Andrzej Chruscinski; Vinicio A. De Jesus Perez; Harvir Singh; Maria Pitsiouni; Marlene Rabinovitch; Paul J. Utz; John P. Cooke is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Cholinergic modulation of angiogenesis: Role of the 7 nicotinic acetylcholine receptor about?
## Abstract Pathological angiogenesis contributes to tobacco‐related diseases such as malignancy, atherosclerosis and age‐related macular degeneration. Nicotine acts on endothelial nicotinic acetylcholine receptors (nAChRs) to activate endothelial cells and to augment pathological angiogenesis. In the current study, we studied nAChR subunits involved in these actions. We detected mRNA for all mammalian nAChR subunits except α~2~, α~4~, γ, and δ in four different types of ECs. Using siRNA methodology, we found that the α~7~ nAChR plays a dominant role in nicotine‐induced cell signaling (assessed by intracellular calcium and NO imaging, and studies of protein expression and phosphorylation), as well as nicotine‐activated EC functions (proliferation, survival, migration, and tube formation). The α~9~ and α~7~ nAChRs have opposing effects on nicotine‐induced cell proliferation and survival. Our studies reveal a critical role for the α~7~ nAChR in mediating the effects of nicotine on the endothelium. Other subunits play a modulatory role. These findings may have therapeutic implications for diseases characterized by pathological angiogenesis. J. Cell. Biochem. 108: 433–446, 2009. © 2009
Who reads Cholinergic modulation of angiogenesis: Role of the 7 nicotinic acetylcholine receptor?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jenny C.F. Wu; Andrzej Chruscinski; Vinicio A. De Jesus Perez; Harvir Singh; Maria Pitsiouni; Marlene Rabinovitch; Paul J. Utz; John P. Cooke
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)