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Can I read Oroxylin a reverses multi-drug resistance of human hepatoma BEL7402/5-FU cells via downregulation of P-glycoprotein expression by inhibiting NF-κB signaling pathway on EtoBox?
Oroxylin a reverses multi-drug resistance of human hepatoma BEL7402/5-FU cells via downregulation of P-glycoprotein expression by inhibiting NF-κB signaling pathway by Hui-Ying Yang; Li Zhao; Zhen Yang; Qing Zhao; Lei Qiang; Jun Ha; Zhi-Yu Li; Qi-Dong You; Qing-Long Guo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Oroxylin a reverses multi-drug resistance of human hepatoma BEL7402/5-FU cells via downregulation of P-glycoprotein expression by inhibiting NF-κB signaling pathway about?
## Abstract In this study, oroxylin A showed strong reversal potency in BEL7402/5‐FU cells and the reversal fold (RF) reached 4.69. Simultaneously, rhodamine‐123 accumulation assay and flow cytometry analysis demonstrated oroxylin A could increase drug accumulation. When combined with oroxylin A, 5‐FU showed inducing apoptosis effect more seriously in DAPI staining experiment. Moreover, the mRNA and protein expression of multi‐drug resistance gene (MDR1) were also decreased by oroxylin A. Further experiments exhibited that oroxylin A can downregulate P‐gp expression through inhibiting nuclear factor‐κB (NF‐κB) signaling pathway, which might be the mechanism of reversal resistance of oroxylin A. In summary, oroxylin A could be a good candidate for the development of new MDR reversal agent and its reversal mechanism probably due to the suppression of P‐gp expression via inhibiting NF‐κB signaling pathway. Mol. Carcinog. © 2011 Wiley Periodicals, Inc.
Who reads Oroxylin a reverses multi-drug resistance of human hepatoma BEL7402/5-FU cells via downregulation of P-glycoprotein expression by inhibiting NF-κB signaling pathway?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Hui-Ying Yang; Li Zhao; Zhen Yang; Qing Zhao; Lei Qiang; Jun Ha; Zhi-Yu Li; Qi-Dong You; Qing-Long Guo
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)