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Epidermal Growth Factor Regulates Apoptosis and Oxidative Stress in a Rat Model of Spinal Cord Injury by Anil Murat Ozturk; Murat Celal Sozbilen; Elvin Sevgili; Taner Dagci; Halit Özyalcin; Guliz Armagan is a Medicine article available to read on EtoBox.

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Spinal cord injury (SCI) leads to vascular damage and disruption of blood-spinal cord barrier which participates in secondary nerve injury. Epidermal growth factor (EGF) is an endogenous protein which regulates cell proliferation, growth and differention. Previous studies reported that EGF exerts neuroprotective effect in spinal cord after SCI. However, the molecular mechanisms underlying EGF-mediated protection in different regions of nervous system have not shown yet. In this study, we aimed to examine possible anti-apoptotic and protective roles of EGF not only in spinal cord but also in brain following SCI. Twenty-eight adult rats were divided into four groups of seven animals each as follows: sham, trauma (SCI), SCI + EGF and SCI + methylprednisolone (MP) groups. The functional neurological deficits due to the SCI were assessed by behavioral analysis using the Basso, Beattie and Bresnahan (BBB) open-field locomotor test. The alterations in pro-/anti-apoptotic protein levels and antioxidant enzyme activities were measured in spinal cord and frontal cortex. In our study, EGF promoted locomotor recovery and motor neuron survival of SCI rats. EGF treatment significantly decreased

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Author

Anil Murat Ozturk; Murat Celal Sozbilen; Elvin Sevgili; Taner Dagci; Halit Özyalcin; Guliz Armagan

Published

2018

Language

EN

Field

Medicine (Health Sciences)