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Can I read Aging and Nuclear Organization: Lamins and Progeria on EtoBox?
Aging and Nuclear Organization: Lamins and Progeria by Leslie C Mounkes; Colin L Stewart is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Aging and Nuclear Organization: Lamins and Progeria about?
The discoveries of at least eight human diseases arising from mutations in LMNA, which encodes the nuclear A-type lamins, have revealed the nuclear envelope as an organelle associated with a variety of fundamental cellular processes. The most recently discovered diseases associated with LMNA mutations are the premature aging disorders Hutchinson-Gilford progeria syndrome (HGPS) and atypical Werner's syndrome. The phenotypes of both HGPS patients and a mouse model of progeria suggest diverse compromised tissue functions leading to defects reminiscent of aging. Aspects of the diseases associated with disrupted nuclear envelope/lamin functions may be explained by decreased cellular proliferation, loss of tissue repair capability and a decline in the ability to maintain a differentiated state.
Who reads Aging and Nuclear Organization: Lamins and Progeria?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Leslie C Mounkes; Colin L Stewart
- Publisher
- Elsevier BV
- Published
- 2004
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)