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Inhibitory Control of Sharp-wave Ripple Duration During Learning in Hippocampal Recurrent Networks by Bert Vancura; Tristan Geiller; Andres Grosmark; Vivian Zhao; Attila Losonczy is a Neuroscience article available to read on EtoBox.

What is Inhibitory Control of Sharp-wave Ripple Duration During Learning in Hippocampal Recurrent Networks about?

Recurrent excitatory connections in hippocampal regions CA3 and CA2 are thought to play a key role in the generation of sharp-wave ripples (SWRs), electrophysiological oscillations tightly linked with learning and memory consolidation. However, it remains unknown how defined populations of inhibitory interneurons regulate these events during behavior. Here, we use large-scale, three-dimensional calcium imaging and retrospective molecular identification in the mouse hippocampus to characterize molecularly identified CA3 and CA2 interneuron activity during SWR-associated memory consolidation and spatial navigation. We describe subtype-and region-specific responses during behaviorally distinct brain states and find that SWRs are preceded by decreased cholecystokinin-expressing interneuron activity and followed by increased parvalbumin-expressing basket cell activity. The magnitude of these dynamics correlates with both SWR duration and behavior during hippocampal-dependent learning. Together these results assign subtype-and region-specific roles for inhibitory circuits in coordinating operations and learning-related plasticity in hippocampal recurrent circuits.

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Author

Bert Vancura; Tristan Geiller; Andres Grosmark; Vivian Zhao; Attila Losonczy

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)