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Can I read Tumor Microenvironments Self-activated Nanoscale Metal-organic Frameworks for Ferroptosis Based Cancer Chemodynamic/photothermal/chemo Therapy on EtoBox?
Tumor Microenvironments Self-activated Nanoscale Metal-organic Frameworks for Ferroptosis Based Cancer Chemodynamic/photothermal/chemo Therapy by Yu Liang; Li Zhang; Chao Peng; Shiyu Zhang; Siwen Chen; Xin Qian; Wanxian Luo; Qing Dan; Yongyan Ren; Yingjia Li; Bingxia Zhao is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Tumor Microenvironments Self-activated Nanoscale Metal-organic Frameworks for Ferroptosis Based Cancer Chemodynamic/photothermal/chemo Therapy about?
Ferroptosis, as a newly discovered cell death form, has become an attractive target for precision cancer therapy. Several ferroptosis therapy strategies based on nanotechnology have been reported by either increasing intracellular iron levels or by inhibition of glutathione (GSH)-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4). However, the strategy by simultaneous iron delivery and GPX4 inhibition has rarely been reported. Herein, novel tumor microenvironments (TME)-activated metal-organic frameworks involving Fe & Cu ions bridged by disulfide bonds with PEGylation (FCSP MOFs) were developed, which would be degraded specifically under the redox TME, simultaneously achieving GSH-depletion induced GPX4 inactivation and releasing Fe ions to produce ROS __via__ Fenton reaction, therefore causing ferroptosis. More ROS could be generated by the acceleration of Fenton reaction due to the released Cu ions and the intrinsic photothermal capability of FCSP MOFs. The overexpressed GSH and H~2~O~2~ in TME could ensure the specific TME self-activated therapy. Better tumor therapeutic efficiency could be achieved by doxorubicin (DOX) loading since it can not only cause apoptosis
Who reads Tumor Microenvironments Self-activated Nanoscale Metal-organic Frameworks for Ferroptosis Based Cancer Chemodynamic/photothermal/chemo Therapy?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yu Liang; Li Zhang; Chao Peng; Shiyu Zhang; Siwen Chen; Xin Qian; Wanxian Luo; Qing Dan; Yongyan Ren; Yingjia Li; Bingxia Zhao
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)