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“Tectonic” hippocampal malformations in patients with temporal lobe epilepsy by Robert S Sloviter; Hemant S Kudrimoti; Kenneth D Laxer; Nicholas M Barbaro; Stephen Chan; Lawrence J Hirsch; Robert R Goodman; Timothy A Pedley is a Medicine article available to read on EtoBox.

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Histological analysis of hippocampi removed en bloc during surgical treatment of temporal lobe epilepsy revealed a subgroup of patients with bulbous expansions of the CA1 pyramidal cell/subicular layers that were consistently accompanied by "tectonic" invaginations of the adjacent dentate gyrus. Most hippocampi containing the CA1/subicular anomaly and the tectonically deformed dentate gyrus exhibited minor cell loss compared to hippocampi with typical hippocampal sclerosis, and retrospective analysis revealed that conventional imaging methods usually failed to detect subtle hippocampal atrophy or abnormal signal characteristics in patients with this anomaly. Cells within the anomaly exhibited the spherical appearance of undifferentiated pyramidal layer neurons, and were immunopositive for the neuronal marker NeuN. Immunostaining for the synaptic marker ␤-synuclein suggested abnormal dentate gyrus lamination in segments containing the pyramidal cell layer anomaly, but not in unaffected areas of the same specimens. Despite differences in the extent of neuronal loss between patients with hippocampal sclerosis and those with the CA1/subicular anomaly, the incidence of antecedent febril

Who reads “Tectonic” hippocampal malformations in patients with temporal lobe epilepsy?

Author

Robert S Sloviter; Hemant S Kudrimoti; Kenneth D Laxer; Nicholas M Barbaro; Stephen Chan; Lawrence J Hirsch; Robert R Goodman; Timothy A Pedley

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)

Published

2004

Language

EN

Field

Medicine (Health Sciences)