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Can I read High-throughput Single-strand Conformation Polymorphism Analysis by Capillary Electrophoresis on EtoBox?
High-throughput Single-strand Conformation Polymorphism Analysis by Capillary Electrophoresis by Jicun Ren is a Chemistry article available to read on EtoBox.
What is High-throughput Single-strand Conformation Polymorphism Analysis by Capillary Electrophoresis about?
Mutation detection plays a great role in genetic and medical research and clinical diagnosis of inherited diseases and particular cancers. Single-strand conformation polymorphism (SSCP) analysis is one of the most popular methods for detection of mutations. Recently, automated capillary electrophoresis (CE) systems have been used in SSCP analysis instead of conventional slab gel electrophoresis. SSCP analysis in combination with CE is a rapid, simple, sensitive and high-throughput mutation screening tool, and has been successfully applied for mutation detection involving human tumor suppressor genes, oncogenes and disease-causing genes. The new technique has a great potential for mutation screening of large numbers of samples in clinical diagnosis. This review discusses basic issues about the methodology of SSCP analysis based on CE and summarizes several key applications.
Who reads High-throughput Single-strand Conformation Polymorphism Analysis by Capillary Electrophoresis?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Jicun Ren
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-4347)
- Published
- 2000
- Language
- EN
- Field
- Chemistry (Physical Sciences)