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Pharmacological emergency management of agitation in children and young people: protocol for a randomised controlled trial of oral medication (PEAChY-O) by Bourke, Elyssia M (author);Borland, Meredith L (author);Kochar, Amit (author);George, Shane (author);Shellshear, Deborah (author);Jani, Shefali (author);Perkins, Kent (author);Tham, Doris (author);Gordon, Michael Solomon (author);Klein, Kate (author);Prakash, Chidambaram (author);Lee, Katherine (author);Davidson, Andrew (author);Knott, Jonathan C (author);Craig, Simon (author);Babl, Franz E (author) is a Medicine article available to read on EtoBox.

What is Pharmacological emergency management of agitation in children and young people: protocol for a randomised controlled trial of oral medication (PEAChY-O) about?

## Introduction Acute severe behavioural disturbance (ASBD) is a condition seen with increasing frequency in emergency departments (EDs) in adults and young people. Despite the increasing number of presentations and significant associated risks to patients, families and caregivers, there is limited evidence to guide the most effective pharmacological management in children and adolescents. The aim of this study is to determine whether a single dose of oral olanzapine is more effective than a dose of oral diazepam at successfully sedating young people with ASBD. ## Methods and analysis This study is a multicentre, open-label, superiority randomised controlled trial. Young people aged between 9 years and 17 years and 364 days presenting to an ED with ASBD who are deemed to require medication for behavioural containment will be recruited to the study. Participants will be randomised in a 1:1 allocation between a single weight-based dose of oral olanzapine and oral diazepam. The primary outcome is the proportion of participants who achieve successful sedation at 1-hour post randomisation without the need for additional sedation. Secondary outcomes will include assessing for adverse eve

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Author

Bourke, Elyssia M (author);Borland, Meredith L (author);Kochar, Amit (author);George, Shane (author);Shellshear, Deborah (author);Jani, Shefali (author);Perkins, Kent (author);Tham, Doris (author);Gordon, Michael Solomon (author);Klein, Kate (author);Prakash, Chidambaram (author);Lee, Katherine (author);Davidson, Andrew (author);Knott, Jonathan C (author);Craig, Simon (author);Babl, Franz E (author)

Publisher

BMJ Publishing Group

Published

2023

Language

EN

Field

Medicine (Health Sciences)