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Three-dimensional (3D) scaffolds as powerful weapons for tumor immunotherapy by Shuyan Han; Jun Wu is a Engineering article available to read on EtoBox.

What is Three-dimensional (3D) scaffolds as powerful weapons for tumor immunotherapy about?

Though increasing understanding and remarkable clinical successes have been made, enormous challenges remain to be solved in the field of cancer immunotherapy. In this context, biomaterial-based immunomodulatory strategies are being developed to boost antitumor immunity. For the local immunotherapy, macroscale biomaterial scaffolds with 3D network structures show great superiority in the following aspects: facilitating the encapsulation, localized delivery, and controlled release of immunotherapeutic agents and even immunocytes for more efficient immunomodulation. The concentrating immunomodulation __in situ__ could minimize systemic toxicities, but still exert abscopal effects to harness the power of overall anticancer immune response for eradicating malignancy. To promote such promising immunotherapies, the design requirements of macroscale 3D scaffolds should comprehensively consider their physicochemical and biological properties, such as porosity, stiffness, surface modification, cargo release kinetics, biocompatibility, biodegradability, and delivery modes. To date, increasing studies have focused on the relationships between these parameters and the biosystems which will gui

Who reads Three-dimensional (3D) scaffolds as powerful weapons for tumor immunotherapy?

Author

Shuyan Han; Jun Wu

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Engineering (Physical Sciences)