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A Long Lifetime and Highly Sensitive Wearable Microneedle Sensor for the Continuous Real-time Monitoring of Glucose in Interstitial Fluid by Sijie Yin; Zhiqiang Yu; NingNing Song; Zhanjun Guo; Wei Li; Jinhang Ma; Xiaoyan Wang; Junyao Liu; Minmin Liang is a Engineering article available to read on EtoBox.
What is A Long Lifetime and Highly Sensitive Wearable Microneedle Sensor for the Continuous Real-time Monitoring of Glucose in Interstitial Fluid about?
The short lifetime and low sensitivity of the current glucose electrochemical sensors are two major issues for implementing continuous real-time monitoring of glucose in vivo. Here we show that a unique microneedlebased glucose monitoring skin patch (termed here MGMSP) can continuously measure glucose in real time in live animals with micromolar sensitivity and over 14 days of service life. This MGMSP employs a glucose oxidase (GOD) and carbon nanotube (CNT) modified hollow syringe as electrochemical sensor for glucose monitoring, an integrated circuit for signal processing and transmission, and the real-time glucose levels are displayed on smartphone via Bluetooth. The designed microneedle device protects the stability of the sensing molecules immobilized within the inner surface of hollow syringe and simultaneously the interior space of hollow syringe substantially increases the amount of immobilized sensing molecules. This microneedle design thus extends the lifetime as well as improves the detection sensitivity. The final MGMSP enables the continuous real-time monitoring of glucose in the interstitial fluid of live rats. This innovative microneedle-based MGMSP could potentially
Who reads A Long Lifetime and Highly Sensitive Wearable Microneedle Sensor for the Continuous Real-time Monitoring of Glucose in Interstitial Fluid?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Sijie Yin; Zhiqiang Yu; NingNing Song; Zhanjun Guo; Wei Li; Jinhang Ma; Xiaoyan Wang; Junyao Liu; Minmin Liang
- Publisher
- Elsevier BV
- Published
- 2024
- Language
- EN
- Field
- Engineering (Physical Sciences)