Can I read Asymmetric Synthesis Of 2-substituted 3-amino-4- Cyanopyrroles Via A Two-step Procedure Consisting Of A Snv Reaction On Ethoxymethylenemalononitrile Followed By A Thorpe-ziegler Cyclization on EtoBox?

Asymmetric Synthesis Of 2-substituted 3-amino-4- Cyanopyrroles Via A Two-step Procedure Consisting Of A Snv Reaction On Ethoxymethylenemalononitrile Followed By A Thorpe-ziegler Cyclization by Sofia Botsi; Georgia Tsolomiti; Stylianos Hamilakis; Athanase Tsolomitis is a Chemistry article available to read on EtoBox.

What is Asymmetric Synthesis Of 2-substituted 3-amino-4- Cyanopyrroles Via A Two-step Procedure Consisting Of A Snv Reaction On Ethoxymethylenemalononitrile Followed By A Thorpe-ziegler Cyclization about?

An asymmetric synthesis of 2-Substituted 3-amino-4-cyanopyrroles via a two-step procedure consisting of a nucleophilic vinylic substitution (SNV), of ethoxymethylenemalononitrile (EMM), with optically pure α-amino acid esters, resulting to the corresponding aminomethylemalononitriles, followed by a Thorpe-Ziegler cyclization, is described. The pyrrole moiety is among the more widespread heterocyclic structures in natural products, 1,2 drugs, 3 ' 4 conducting materials, 5,6 insecticides 7 and others. 3-Aminopyrrole derivatives, have been shown to exhibit antibacterial, antiviral and anticonvulsant activities, 8 specifically 3-aminopyrrole-2-carboxylates have exhibited anticonvulsant activity by blocking sodium channels. 9 Moreover 3-amino-4-cyanopyrroles have been used for synthesizing pyrolopyrimidines as new anticancer drugs. 10

Who reads Asymmetric Synthesis Of 2-substituted 3-amino-4- Cyanopyrroles Via A Two-step Procedure Consisting Of A Snv Reaction On Ethoxymethylenemalononitrile Followed By A Thorpe-ziegler Cyclization?

Author

Sofia Botsi; Georgia Tsolomiti; Stylianos Hamilakis; Athanase Tsolomitis

Publisher

Walter de Gruyter GmbH

Published

2008

Language

EN

Field

Chemistry (Physical Sciences)