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Transcriptome changes and cAMP oscillations in an archaeal cell cycle by Anke Baumann; Christian Lange; Jörg Soppa is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Transcriptome changes and cAMP oscillations in an archaeal cell cycle about?

## Background The cell cycle of all organisms includes mass increase by a factor of two, replication of the genetic material, segregation of the genome to different parts of the cell, and cell division into two daughter cells. It is tightly regulated and typically includes cell cycle-specific oscillations of the levels of transcripts, proteins, protein modifications, and signaling molecules. Until now cell cycle-specific transcriptome changes have been described for four eukaryotic species ranging from yeast to human, but only for two prokaryotic species. Similarly, oscillations of small signaling molecules have been identified in very few eukaryotic species, but not in any prokaryote. ## Results A synchronization procedure for the archaeon __Halobacterium salinarum__ was optimized, so that nearly 100% of all cells divide in a time interval that is 1/4^th^ of the generation time of exponentially growing cells. The method was used to characterize cell cycle-dependent transcriptome changes using a genome-wide DNA microarray. The transcript levels of 87 genes were found to be cell cycle-regulated, corresponding to 3% of all genes. They could be clustered into seven groups with differe

Who reads Transcriptome changes and cAMP oscillations in an archaeal cell cycle?

Author

Anke Baumann; Christian Lange; Jörg Soppa

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2000]-2018.; Springer Science and Business Media LLC (ISSN 1471-2121)

Published

2007

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)