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Interaction of the CMTM7 rs347134 Polymorphism with Dietary Patterns and the Risk of Obesity in Han Chinese Male Children by Qi Zhu; Kun Xue; Hong Wei Guo; Fei Fei Deng; Yu Huan Yang is a Medicine article available to read on EtoBox.

What is Interaction of the CMTM7 rs347134 Polymorphism with Dietary Patterns and the Risk of Obesity in Han Chinese Male Children about?

A genome-wide association study (GWAS) in the Han Chinese population had found that single nucleotide polymorphism (SNP) on the CMTM7 gene rs347134 was significantly associated with Body Mass Index (BMI). In the present study, the association of the rs347134 SNP with obesity and its interaction with dietary patterns (DPs) were explored in Han Chinese children. This cross-sectional study group included 1292 children, in whom obesity-related indicators were evaluated, the rs347134 SNP was genotyped by improved Multiple Ligase Detection Reaction (iMLDR), and the DPs were identified by principal component factor analysis. The GG genotype exhibited higher odds of general overweight/obesity (__P__ = 0.038) and central obesity (__P__ = 0.039) than AA + GA genotypes in boys. Four DPs of boys were identified: healthy balanced (HBDP), nuts and sweets-based (NSDP), animal food-based (AFDP), and wheaten and dairy-based (WDDP). Boys with the GG genotype were significantly more inclined to AFDP (__P__ = 0.028) and had a shorter sleep duration (__P__ = 0.031). Significant interactions were observed; boys with the GG genotype displayed a higher LDL in AFDP (__P__ = 0.031) and higher FBG in NSDP (_

Who reads Interaction of the CMTM7 rs347134 Polymorphism with Dietary Patterns and the Risk of Obesity in Han Chinese Male Children?

Author

Qi Zhu; Kun Xue; Hong Wei Guo; Fei Fei Deng; Yu Huan Yang

Publisher

MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI, 2003-; ScienceOpen (ISSN 1660-4601)

Published

2020

Language

EN

Field

Medicine (Health Sciences)