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Can I read Phenylacetic acid derivatives as hPPAR agonists on EtoBox?
Phenylacetic acid derivatives as hPPAR agonists by Conrad Santini; Gregory D Berger; Wei Han; Ralph Mosley; Karen MacNaul; Joel Berger; Thomas Doebber; Margaret Wu; David E Moller; Richard L Tolman; Soumya P Sahoo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Phenylacetic acid derivatives as hPPAR agonists about?
Beginning with the weakly active lead structure 1, a new series of hPPAR agonists was developed. In vivo glucose and triglyceride lowering activity was obtained by homologation and oxamination to 3, then conversion to substituted benzisoxazoles 4 and 5. Further manipulation afforded benzofurans 6 and 7. Compound 7 was of comparable potency as a glucose and triglyceride lowering agent in insulin resistant rodents to BRL 49653.
Who reads Phenylacetic acid derivatives as hPPAR agonists?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Conrad Santini; Gregory D Berger; Wei Han; Ralph Mosley; Karen MacNaul; Joel Berger; Thomas Doebber; Margaret Wu; David E Moller; Richard L Tolman; Soumya P Sahoo
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2003
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)