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Hydroxylapatite nanorods: An efficient and promising carrier for gene transfection by Guo-Jun Wu; Lin-Zhu Zhou; Ke-Wei Wang; Feng Chen; Ying Sun; You-Rong Duan; Ying-Jie Zhu; Hong-Chen Gu is a Chemistry article available to read on EtoBox.
What is Hydroxylapatite nanorods: An efficient and promising carrier for gene transfection about?
Calcium phosphate (CaP) has been used as the vector for gene transfection in the past three decades with the characteristics of excellent biocompatibility and biodegradability. However, clinical application of calcium phosphate is still not popular due to poor-controlling of DNA/CaP complex preparation and its low transfection efficiency. In this study, block copolymer (PLGA-mPEG) assisted synthesis of hydroxylapatite (HAP) nanorods and DNA post-adsorbing method for transfection in vitro have been reported. By hydrothermal treatment, HAP nanorods with relatively uniform sizes of ~100 nm in length and ~25 nm in diameter and high crystallinity were prepared, which were characterized by TEM, XRD and FTIR measurements. In the presence of Ca(2+) (0.2 mol/L), HAP nanorods showed ultra-high DNA loading capacity, which was significantly enhanced by one or two magnitude compared with the recently reported high loading capacity mesoporous silica vectors. HAP nanorods, therefore, have a great potential as the gene vector to deliver DNA into the cells effectively and safely.
Who reads Hydroxylapatite nanorods: An efficient and promising carrier for gene transfection?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Guo-Jun Wu; Lin-Zhu Zhou; Ke-Wei Wang; Feng Chen; Ying Sun; You-Rong Duan; Ying-Jie Zhu; Hong-Chen Gu
- Publisher
- Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0021-9797)
- Published
- 2010
- Language
- EN
- Field
- Chemistry (Physical Sciences)