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Effects of Early Life Trauma Are Dependent on Genetic Predisposition: a Rat Study by Toni-Lee Sterley; Fleur M Howells; Vivienne A Russell is a Neuroscience article available to read on EtoBox.

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## Background Trauma experienced early in life increases the risk of developing a number of psychological and/or behavioural disorders. It is unclear, however, how genetic predisposition to a behavioural disorder, such as attention-deficit/hyperactivity disorder (ADHD), modifies the long-term effects of early life trauma. There is substantial evidence from family and twin studies for susceptibility to ADHD being inherited, implying a strong genetic component to the disorder. In the present study we used an inbred animal model of ADHD, the spontaneously hypertensive rat (SHR), to investigate the long-term consequences of early life trauma on emotional behaviour in individuals predisposed to developing ADHD-like behaviour. ## Methods We applied a rodent model of early life trauma, maternal separation, to SHR and Wistar-Kyoto rats (WKY), the normotensive control strain from which SHR were originally derived. The effects of maternal separation (removal of pups from dam for 3 h/day during the first 2 weeks of life) on anxiety-like behaviour (elevated-plus maze) and depressive-like behaviour (forced swim test) were assessed in prepubescent rats (postnatal day 28 and 31). Basal levels of

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Author

Toni-Lee Sterley; Fleur M Howells; Vivienne A Russell

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2005-; Springer Science and Business Media LLC (ISSN 1744-9081)

Published

2011

Language

EN

Field

Neuroscience (Life Sciences)