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In vivo treatment with recombinant IL‐12 protects C57BL/6J mice against secondary alveolar echinococcosis by ISABELLE EMERY; CLAUDE LECLERC; KAPPRASEUTH SENGPHOMMACHANH; DOMINIQUE ANGÈLE VUITTON; MARTINE LIANCE is a Medicine article available to read on EtoBox.

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__Using an experimental model of hepatic__ Echinococcus multilocularis __infection in C57BL/6J mice, intraperitoneal administration of 0.8 μg of recombinant IL‐12 to mice with an established infection was shown to reduce the parasite burden as soon as two weeks after the end of treatment. At that time,__ in vitro Echinococcus multilocularis__‐induced spleen T cell proliferative responses as well as IFN‐γ and IL‐5 production were higher in IL‐12 treated mice than in untreated mice. Administration of 0.8 μg of IL‐12 at the time of infection was shown to be without effect on the parasite establishment. However, this treatment greatly inhibited the subsequent metacestode development. Indeed, ten weeks after infection, it induced a complete healing in 37.5% of mice. At that time, the development of metastases was inhibited in 68.75% of IL‐12‐treated mice. This reduction of parasite burden was mainly associated with a strong proliferation of spleen cells to__ E. multilocularis __antigen and with a high IFN‐γ production. Altogether, our results show that IL‐12 is of crucial importance in inhibiting the larval growth after the metacestode establishment in the liver and suggest that this cy

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Author

ISABELLE EMERY; CLAUDE LECLERC; KAPPRASEUTH SENGPHOMMACHANH; DOMINIQUE ANGÈLE VUITTON; MARTINE LIANCE

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; FASEB (ISSN 0141-9838)

Published

1998

Language

EN

Field

Medicine (Health Sciences)