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Repeated Administration of Alpha-hederin Results in Alterations in Maternal Zinc Status and Adverse Developmental Outcome in the Rat by Duffy, Jodie Y.; Baines, Donald; Overmann, Gary J.; Keen, Carl L.; Daston, George P. is a Medicine article available to read on EtoBox.

What is Repeated Administration of Alpha-hederin Results in Alterations in Maternal Zinc Status and Adverse Developmental Outcome in the Rat about?

The administration of alpha-hederin, an inducer of metallothionein, results in a secondary zinc deficiency that may be an important maternally mediated mechanism of developmental toxicity. Previous studies have shown adverse developmental outcome with a single administration of alpha-hederin to rats on gestation day (GD) 8 or 11. The objective of this study was to determine whether dosing of alpha-hederin throughout organogenesis would result in a sustained elevation of maternal hepatic metallothionein and subsequent developmental abnormalities. Rats were administered dosage levels of 0 (vehicle only), 20, or 30 mumol/kg from GD 6-15. Maternal hepatic metallothionein levels were 10-fold higher on GD 16 in the treatment groups than the controls. Consequently, liver zinc concentrations increased 60% and 54%, whereas plasma levels decreased 23% and 33% in the 20 and 30 mumol/kg treatment groups, respectively. At GD 20, mean fetal weights of the treatment litters were 11% less than control litters. The administration of alpha-hederin resulted in a threefold increase in the number of offspring that exhibited developmental abnormalities, including visceral and skeletal malformations. Fol

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Author

Duffy, Jodie Y.; Baines, Donald; Overmann, Gary J.; Keen, Carl L.; Daston, George P.

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0040-3709)

Published

1998

Language

EN

Field

Medicine (Health Sciences)