Opening book details…
Can I read Sickle Cell Disease and Acute Leukemia: One Case Report and an Extensive Review on EtoBox?
Sickle Cell Disease and Acute Leukemia: One Case Report and an Extensive Review by Giovanna Cannas; Solène Poutrel; Maël Heiblig; Hélène Labussière; Marie-Virginie Larcher; Xavier Thomas; Arnaud Hot is a Medicine article available to read on EtoBox.
What is Sickle Cell Disease and Acute Leukemia: One Case Report and an Extensive Review about?
Population-based studies and case reports suggest that there may be an increased risk of acute leukemia associated with sickle cell disease (SCD). Following the description of a new case report, an extensive review of the literature identified 51 previously described cases. Most cases study showed myelodysplastic features confirmed, when available, by genetic markers such as chromosome 5 and/or chromosome 7 abnormalities and TP53 gene mutations. The increased risk of leukemogenesis is certainly multifactorial and related to the pathophysiologic mechanisms of the clinical manifestations of SCD. Chronic hemolysis and secondary hemochromatosis may cause increased chronic inflammation, resulting in persistent marrow stress, which could potentially compromise the genomic stability of the hematopoietic stem cells generating genomic damage and somatic mutations over the course of SCD and its treatment, resulting in a clone that led to acute myeloid leukemia.
Who reads Sickle Cell Disease and Acute Leukemia: One Case Report and an Extensive Review?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Giovanna Cannas; Solène Poutrel; Maël Heiblig; Hélène Labussière; Marie-Virginie Larcher; Xavier Thomas; Arnaud Hot
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)