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Value of Fluorescence Endoscopy for the Early Diagnosis of Laryngeal Cancer and Its Precursor Lesions by Marcel Kraft; Christian Stephan Betz; Andreas Leunig; Christoph Arens is a Medicine article available to read on EtoBox.

What is Value of Fluorescence Endoscopy for the Early Diagnosis of Laryngeal Cancer and Its Precursor Lesions about?

## Abstract ## Background Fluorescence endoscopy is used for the early detection and delineation of laryngeal cancer and its precursor lesions. No systematic review of these promising imaging techniques has yet been performed. ## Methods A systematic review of the published literature and meta‐analysis of data extracted from 16 included studies were performed. A total of 1000 laryngeal lesions were examined by autofluorescence endoscopy (AFE), 318 mucosal changes by induced fluorescence endoscopy (IFE), and 679 laryngeal pathologies underwent normal white light endoscopy (WLE). ## Results In identifying precancerous and cancerous lesions of the larynx, sensitivity (91% vs 73%), specificity (84% vs 79%), and accuracy (88% vs 77%) of AFE were superior to WLE alone, whereas IFE showed an even higher sensitivity (95% vs 73%) at the expense of specificity (62% vs 79%). Therefore, AFE also achieved a higher specificity (84% vs 62%) and accuracy (88% vs 76%) than did IFE in detecting these kinds of lesions. However, the sensitivity (91% vs 95%) did not differ significantly between both methods. ## Conclusions This meta‐analysis confirms that fluorescence endoscopy is highly effective in t

Who reads Value of Fluorescence Endoscopy for the Early Diagnosis of Laryngeal Cancer and Its Precursor Lesions?

Author

Marcel Kraft; Christian Stephan Betz; Andreas Leunig; Christoph Arens

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1043-3074)

Published

2010

Language

EN

Field

Medicine (Health Sciences)