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Altered potassium homeostasis in Crohn's disease by O. Schober; C. Bossaller; L. Lehr; H. Hundeshagen is a Medicine article available to read on EtoBox.
What is Altered potassium homeostasis in Crohn's disease about?
The total body potassium (TBK), serum potassium, and the number of red blood cell ouabain-binding sites was studied in 94 patients with Crohn's disease. TBK was measured by counting the endogenous 40K in a whole body counter. TBK was 87% +/- 13% in 94 patients with Crohn's disease, while in control subjects, it was 97% +/- 12% (n = 24). This significant reduction in TBK was accompanied by normal serum potassium levels (4.4 +/- 0.5 mM). TBK was significantly correlated with the Crohn's disease activity index (r = 0.79, n = 113, P less than 0.01). The number of red cell ouabain binding sites measured by equilibrium binding of 3H-ouabain showed a significant increase in the number of Na-K pumps in Crohn's disease (396 +/- 65, n = 27) compared with the control group (290 +/- 45; n = 24). These results support the suggestion that changes in TBK may regulate the synthesis of Na-K pump molecules. The total body potassium depletion and the need for a preoperative nutritional support in Crohn's disease are discussed.
Who reads Altered potassium homeostasis in Crohn's disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- O. Schober; C. Bossaller; L. Lehr; H. Hundeshagen
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0340-6997)
- Published
- 1982
- Language
- EN
- Field
- Medicine (Health Sciences)