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Rapid Repair of Titanium Particle‐induced Osteolysis Is Dramatically Reduced in Aged Mice by Scott G. Kaar; Ashraf A. Ragab; Sarah J. Kaye; B. Alper Kilic; Tetsuya Jinno; Victor M. Goldberg; Yanming Bi; Matthew C. Stewart; John R. Carter; Edward M. Greenfield is a Medicine article available to read on EtoBox.

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## Abstract Aseptic loosening is the most common cause of orthopaedic implant failure. This process is thought to be due to osteolysis induced by implant‐derived wear particles. Teitelbaum and colleagues have recently developed a promising murine calvarial model of wear particle‐induced osteolysis. However, prior to this study, this model had only been assessed qualitatively. We now report a reproducible, quantitative version of the calvarial model of wear particle‐induced osteolysis, in which the extent of osteolysis (and repair) of entire parietal bones is assessed by histomorphometry of contact microradiographs. Using this model, we found that the osteolytic response is transient and rapidly repaired in one month old mice. The extent of osteolysis peaks 7 days after particle implantation and returns to baseline levels by 13 days. A similar amount of osteolysis and even more extensive repair is observed when particles are implanted repeatedly. In contrast, aged mice develop progressive osteolysis with no detectable repair. As a result, 26 month old mice have approximately 17‐fold more osteolysis than one month old mice 21 days after particle implantation. Skeletally mature, adult

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Author

Scott G. Kaar; Ashraf A. Ragab; Sarah J. Kaye; B. Alper Kilic; Tetsuya Jinno; Victor M. Goldberg; Yanming Bi; Matthew C. Stewart; John R. Carter; Edward M. Greenfield

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)

Published

2001

Language

EN

Field

Medicine (Health Sciences)