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Can I read Structure-guided design and development of cyclin-dependent kinase 4/6 inhibitors: A review on therapeutic implications on EtoBox?
Structure-guided design and development of cyclin-dependent kinase 4/6 inhibitors: A review on therapeutic implications by Mohd. Yousuf; Manzar Alam; Anas Shamsi; Parvez Khan; Gulam Mustafa Hasan; Qazi M. Rizwanul Haque; Md. Imtaiyaz Hassan is a Materials Science article available to read on EtoBox.
What is Structure-guided design and development of cyclin-dependent kinase 4/6 inhibitors: A review on therapeutic implications about?
Cyclin-dependent kinase 6 (EC 2.7.11.22) play significant roles in numerous biological processes and triggers cell cycle events. CDK6 controlled the transcriptional regulation. A dysregulated function of CDK6 is linked with the development of progression of multiple tumor types. Thus, it is considered as an effective drug target for cancer therapy. Based on the direct roles of CDK4/6 in tumor development, numerous inhibitors developed as promising anti-cancer agents. CDK4/6 inhibitors regulate the G1 to S transition by preventing Rb phosphorylation and E2F liberation, showing potent anti-cancer activity in several tumors, including HR+/HER2- breast cancer. CDK4/6 inhibitors such as abemaciclib, palbociclib, and ribociclib, control cell cycle, provoke cell senescence, and induces tumor cell disturbance in pre-clinical studies. Here, we discuss the roles of CDK6 in cancer along with the present status of CDK4/6 inhibitors in cancer therapy. We further discussed, how structural features of CDK4/6 could be implicated in the design and development of potential anti-cancer agents. In addition, the therapeutic potential and limitations of available CDK4/6 inhibitors are described in detai
Who reads Structure-guided design and development of cyclin-dependent kinase 4/6 inhibitors: A review on therapeutic implications?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Mohd. Yousuf; Manzar Alam; Anas Shamsi; Parvez Khan; Gulam Mustafa Hasan; Qazi M. Rizwanul Haque; Md. Imtaiyaz Hassan
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Materials Science (Physical Sciences)