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What is Z-DNA: Structure and Biological Role about?

This document summarizes research on left-handed Z-DNA structure and its biological function. It discusses how Z-DNA forms in vitro under conditions of negative supercoiling or high salt concentrations. It also reviews evidence that Z-DNA forms in vivo during processes like transcription that introduce negative supercoils into DNA. Experiments in prokaryotes and eukaryotes provide support that Z-DNA exists within living cells and is linked to transcriptional activity levels. The document considers the chall

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