Opening book details…
Can I read Effect of the R126C mutation on the structure and function of the glucose transporter GLUT1: A molecular dynamics simulation study on EtoBox?
Effect of the R126C mutation on the structure and function of the glucose transporter GLUT1: A molecular dynamics simulation study by Xiaoliu Liu; Luguang Liang; Bodeng Wu; Xin Zhang; Xiaoman Zeng; Yurong Deng; Bin Peng; Xiuming Zhang; Lei Zheng is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Effect of the R126C mutation on the structure and function of the glucose transporter GLUT1: A molecular dynamics simulation study about?
Glucose transporter 1 (GLUT1) is responsible for basal glucose uptake and is expressed in most tissues under normal conditions. GLUT1 mutations can cause early-onset absence epilepsy and myoclonus dystonia syndrome (MDS), with MDS potentially lethal. In this study, the effect of the R126C mutation, which is associated with MDS, on structural stability and substrate transport of GLUT1 was investigated. Various bioinformatics tools were used to predict the stability of GLUT1, revealing that the R126C mutation reduces the structural stability of GLUT1. Molecular dynamics (MD) simulations were used to further characterize the effect of the R126C mutation on GLUT1 structural stability. Based on the MD simulations, specific conformational changes and dominant motions of the GLUT1 mutant were characterized by Principal component analysis (PCA). The mutation disrupts hydrogen bonds between substrate-binding residues and glucose, thus likely reducing substrate affinity. The R126C mutation reduces the conformational stability of the protein, and fewer intramolecular hydrogen bonds were present in the mutated GLUT1 when compared with that of wild-type GLUT1. The mutation increased the free en
Who reads Effect of the R126C mutation on the structure and function of the glucose transporter GLUT1: A molecular dynamics simulation study?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Xiaoliu Liu; Luguang Liang; Bodeng Wu; Xin Zhang; Xiaoman Zeng; Yurong Deng; Bin Peng; Xiuming Zhang; Lei Zheng
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Physical Sciences)