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Kinetics of peroxidation of linoleic acid incorporated into DPPC vesicles initiated by the thermal decomposition of 2,2′-azobis(2-amidinopropane) dihydrochloride by Marı́a A. Cubillos; Eduardo A. Lissi; Elsa B. Abuin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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In a previous work [Chem. Phys. Lipids 104 (2000) 49], we have derived the following rate law for the oxidation of lipids in compartmentalized systems: R T =(k 1 /k t ) 0.5 k p [In] 0.5 c 0.5 [LH], where, R T is the total rate of oxidation, k 1 is the rate constant for the production of free radicals, k t and k p are the intra-particle rate constants for the termination and propagation sets, respectively, [In] is the concentration of a water-soluble initiator, c is the concentration of particles, and [LH] is the intra-particle concentration of oxidable lipid. In the present work, we have investigated on the applicability of the proposed kinetic rate law for a system where it takes place the oxidation of a reactive lipid incorporated into an inert matrix. With this purpose, we have measured the rate of oxidation of linoleic acid incorporated into dipalmitoylphosphatidylcholine vesicles initiated by the thermal decomposition of 2,2%-azobis(2-amidinopropane) dihydrochloride as a function of the initiator, particles, and intra-particle LH concentrations. The experimentally determined kinetic orders obtained were 0.54 90.02, 0.48 90.05 and 0.83 9 0.04 for the dependence of the oxidation

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Author

Marı́a A. Cubillos; Eduardo A. Lissi; Elsa B. Abuin

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-3084)

Published

2001

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)