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The Role of Preoperative Mechanical Bowel Preparation and Oral Antibiotics in Prevention of Anastomotic Leakage Following Restorative Resection for Primary Rectal Cancer – a Systematic Review and Meta-analysis by Rikke Bech Hansen; Rogini Balachandran; Thomas Nikolas Valsamidis; Lene Hjerrild Iversen is a Medicine article available to read on EtoBox.

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Purpose Anastomotic leakage after colorectal cancer resection is a feared postoperative complication seen among up till 10-20% of patients, with a higher risk following rectal resection than colon resection. Recent studies suggest that the combined use of preoperative mechanical bowel preparation and oral antibiotics may have a preventive effect on anastomotic leakage. This systematic review aims to explore the association between preoperative mechanical bowel preparation combined with oral antibiotics and the risk of anastomotic leakage following restorative resection for primary rectal cancer. Methods Three databases were systematically searched in February 2022. Studies reporting anastomotic leakage rate in patients, who received mechanical bowel preparation and oral antibiotics before elective restorative resection for primary rectal cancer, were included. A meta-analysis was conducted based on the risk ratios of anastomotic leakage. Results Among 839 studies, 5 studies met the eligibility criteria. The median number of patients were 6111 (80-29,739). The combination of preoperative mechanical bowel preparation and oral antibiotics was associated with a decreased risk of anasto

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Author

Rikke Bech Hansen; Rogini Balachandran; Thomas Nikolas Valsamidis; Lene Hjerrild Iversen

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)