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Can I read Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators on EtoBox?
Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators by Junn Yanagisawa; Yasuo Yanagi; Yoshikazu Masuhiro; Miyuki Suzawa; Michiko Watanabe; Kouji Kashiwagi; Takeshi Toriyabe; Masahiro Kawabata; Kohei Miyazono; Shigeaki Kato is a Medicine article available to read on EtoBox.
What is Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators about?
Cell proliferation and differentiation are regulated by growth regulatory factors such as transforming growth factor–β (TGF-β) and the liphophilic hormone vitamin D. TGF-β causes activation of SMAD proteins acting as coactivators or transcription factors in the nucleus. Vitamin D controls transcription of target genes through the vitamin D receptor (VDR). Smad3, one of the SMAD proteins downstream in the TGF-β signaling pathway, was found in mammalian cells to act as a coactivator specific for ligand-induced transactivation of VDR by forming a complex with a member of the steroid receptor coactivator–1 protein family in the nucleus. Thus, Smad3 may mediate cross-talk between vitamin D and TGF-β signaling pathways.
Who reads Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Junn Yanagisawa; Yasuo Yanagi; Yoshikazu Masuhiro; Miyuki Suzawa; Michiko Watanabe; Kouji Kashiwagi; Takeshi Toriyabe; Masahiro Kawabata; Kohei Miyazono; Shigeaki Kato
- Publisher
- American Association for the Advancement of Science (AAAS)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Social Sciences)