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Differential expression of CD3 and CD7 in T-cell malignancies: a quantitative study by flow cytometry by Lia Ginaldi; Estella Matutes; Nahla Farahat; Massimo De Martinis; Ricardo Morilla; Daniel Catovsky is a Medicine article available to read on EtoBox.
What is Differential expression of CD3 and CD7 in T-cell malignancies: a quantitative study by flow cytometry about?
Most T‐cell antigens are expressed on normal and neoplastic T lymphocytes and for this reason it is not easy to distinguish between the immunophenotype of normal and malignant T cells. We have addressed this problem by comparing the levels of expression of CD3 and CD7 on T lymphocytes from 18 healthy donors with those of 61 cases of T‐cell leukaemia using quantitative flow cytometry with a method that converts fluorescence intensity into number of antigen molecules per cell. Normal T lymphocytes expressed 124 ± 25 CD3 and 20 ± 3 × 10^3^ CD7 molecules per cell. The mean CD3 values were significantly lower in all types of T‐cell leukaemia than in normal T cells ( __P__ < 0.05), with the exception of Sezary syndrome. The lowest CD3 values were found in T‐lymphoblastic leukaemia (T‐ALL), 30 ± 21 × 10^3^, and adult T‐cell leukaemia/lymphoma (ATLL), 38 ± 31 × 10^3^, followed by T‐prolymphocytic leukaemia (T‐PLL), 92 ± 47 × 10^3^, and granular lymphocyte leukaemia (GLL), 95 ± 21 × 10^3^. In contrast, the number of CD7 molecules was significantly higher in T‐ALL, 35 ± 7 × 10^3^ ( __P__ < 0.01), and T‐PLL, 29 ± 12 × 10^3^, than the normal controls ( __P__ < 0.01), whereas ATLL and GLL showe
Who reads Differential expression of CD3 and CD7 in T-cell malignancies: a quantitative study by flow cytometry?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Lia Ginaldi; Estella Matutes; Nahla Farahat; Massimo De Martinis; Ricardo Morilla; Daniel Catovsky
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)