Opening book details…
Can I read Blood Markers of Oxidative Stress Are Strongly Associated with Poorer Prognosis in Colorectal Cancer Patients on EtoBox?
Blood Markers of Oxidative Stress Are Strongly Associated with Poorer Prognosis in Colorectal Cancer Patients by Boakye, Daniel; Jansen, Lina; Schöttker, Ben; Jansen, Eugene H. J. M.; Schneider, Martin; Halama, Niels; Gào, Xin; ChangâClaude, Jenny; Hoffmeister, Michael; Brenner, Hermann is a Medicine article available to read on EtoBox.
What is Blood Markers of Oxidative Stress Are Strongly Associated with Poorer Prognosis in Colorectal Cancer Patients about?
## Abstract Oxidative stress has been implicated in the initiation of several cancers, including colorectal cancer (CRC). Whether it also plays a role in CRC prognosis is unclear. We assessed the associations of two oxidative stress biomarkers (Diacron's reactive oxygen metabolites [d‐ROMs] and total thiol level [TTL]) with CRC prognosis. CRC patients who were diagnosed in 2003 to 2012 and recruited into a population‐based study in Germany (n = 3361) were followed for up to 6 years. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the associations of d‐ROMs and TTL (measured from blood samples collected shortly after CRC diagnosis) with overall survival (OS) and disease‐specific survival (DSS) were estimated using multivariable Cox regression. Particularly pronounced associations of higher d‐ROMs with lower survival were observed in stage IV patients, with patients in the highest (vs lowest) tertile having much lower OS (HR = 1.52, 95% CI = 1.14‐2.04) and DSS (HR = 1.61, 95% CI = 1.20‐2.17). For TTL, strong inverse associations of TTL with mortality were observed within all stages. In patients of all stages, those in the highest (vs lowest) quintile had substantially
Who reads Blood Markers of Oxidative Stress Are Strongly Associated with Poorer Prognosis in Colorectal Cancer Patients?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Boakye, Daniel; Jansen, Lina; Schöttker, Ben; Jansen, Eugene H. J. M.; Schneider, Martin; Halama, Niels; Gào, Xin; ChangâClaude, Jenny; Hoffmeister, Michael; Brenner, Hermann
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)