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What is Evaluating Genome Assemblies With HMM-Flagger about?

HMM-Flagger is a novel reference-free tool designed to detect structural errors in haplotype-resolved genome assemblies by modeling read coverage using a hidden Markov model. It has demonstrated high accuracy in identifying misassemblies in various sequencing data, achieving F1 scores of 78.4% and 60.4% for Pacific Biosciences HiFi and Oxford Nanopore Technologies data, respectively. The tool has shown significant improvements in error detection in assemblies from the Human Pangenome Reference Consortium, c

Author

gay.par.rt23

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EN