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Hepatitis C virus core protein promotes cell proliferation through the upregulation of cyclin E expression levels by Jae‐We Cho; Won‐Ki Baek; Seong‐Il Suh; Se‐Hwan Yang; Jun Chang; Young Chul Sung; Min‐Ho Suh is a Medicine article available to read on EtoBox.
What is Hepatitis C virus core protein promotes cell proliferation through the upregulation of cyclin E expression levels about?
## Aims/background: The hepatitis c virus (hcv) core protein is known to play an important role in hepatocarcinogenesis. recent studies have suggested that the increased proliferation rate of hepatocytes is a major risk factor for the development of hepatocellular carcinoma. in this study, we investigated whether the hcv core protein promotes the cell growth rate through the modulation of cyclin e expression levels. ## Methods/results: Hcv core stable transfectant rat-1 cell lines showed a markedly increased proliferation rate compared to mock cells. cyclin e expression and its associated kinase activities were remarkably increased in hcv core stable transfectants. cyclin e mrna levels were also upregulated in these cell lines. ## Conclusions: Our data suggest that the hcv core protein promotes cell proliferation through upregulation of the cyclin e expression levels, implying this property of hcv core protein plays an important role in hepatocarcinogenesis.
Who reads Hepatitis C virus core protein promotes cell proliferation through the upregulation of cyclin E expression levels?
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- Author
- Jae‐We Cho; Won‐Ki Baek; Seong‐Il Suh; Se‐Hwan Yang; Jun Chang; Young Chul Sung; Min‐Ho Suh
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0106-9543)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)