About this document
Heart Failure and Cognitive Dysfunction by rickyltz is a document available to read on EtoBox.
The study investigates the link between heart failure (HF) and cognitive dysfunction (CD), revealing that intracellular Ca2+ leak through ryanodine receptor type 2 (RyR2) contributes to CD in HF patients. Post-translational modifications of RyR2, driven by hyper-adrenergic signaling, lead to leaky channels that impair cognitive function, which can be mitigated by pharmacological interventions. The findings suggest that HF is a systemic illness that may also induce cardiogenic dementia, emphasizing the need
- Author
- rickyltz
- Language
- EN