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Can I read Dietary Energy Modulation and Autophagy: Exploiting Metabolic Vulnerabilities to Starve Cancer on EtoBox?
Dietary Energy Modulation and Autophagy: Exploiting Metabolic Vulnerabilities to Starve Cancer by Cozzo, Alyssa J.; Coleman, Michael F.; Pearce, Jane B.; Pfeil, Alexander J.; Etigunta, Suhas K.; Hursting, Stephen D. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Dietary Energy Modulation and Autophagy: Exploiting Metabolic Vulnerabilities to Starve Cancer about?
Cancer cells experience unique and dynamic shifts in their metabolic function in order to survive, proliferate, and evade growth inhibition in the resource-scarce tumor microenvironment. Therefore, identification of pharmacological agents with potential to reprogram cancer cell metabolism may improve clinical outcomes in cancer therapy. Cancer cells also often exhibit an increased dependence on the process known as autophagy, both for baseline survival and as a response to stressors such as chemotherapy or a decline in nutrient availability. There is evidence to suggest that this increased dependence on autophagy in cancer cells may be exploitable clinically by combining autophagy modulators with existing chemotherapies. In light of the increased metabolic rate in cancer cells, interest is growing in approaches aimed at "starving" cancer through dietary and pharmacologic interventions that reduce availability of nutrients and pro-growth hormonal signals known to promote cancer progression. Several dietary approaches, including chronic calorie restriction and multiple forms of fasting, have been investigated for their potential anti-cancer benefits, yielding promising results in ani
Who reads Dietary Energy Modulation and Autophagy: Exploiting Metabolic Vulnerabilities to Starve Cancer?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Cozzo, Alyssa J.; Coleman, Michael F.; Pearce, Jane B.; Pfeil, Alexander J.; Etigunta, Suhas K.; Hursting, Stephen D.
- Publisher
- Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2013- (ISSN 2296-634X)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)