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<div><div> <h2>CHAPTER 1</h2> <p><b>Cancer Stem Cells: Similarities and Variations in the Theme of Normal Stem Cells</b></p> <p>SHARMILA BAPAT, ANNE COLLINS, MICHAEL DEAN, KENNETH NEPHEW, and SURAIYA RASHEED</p> <br> <p><b>1.1 INTRODUCTION</b></p> <p>Then we have Beard's "germ-cell" hypothesis, in which he holds that many of the germ-cells in the growing embryo fail to reach their proper position—the generative areas—and settle down and become quiescent in some somatic tissue of the embryo. They may at some later date become active in some way, and so give rise to a cellular proliferation that may imitate the structure in which they grow, so giving rise to new growths.</p> <p><i>—Encyclopedia Britannica</i>, 1911</p> <br> <p>Tumors were first likened to embryonic cells by the Scottish embryologist John Beard, who early in the twentieth century proposed a germ cell theory of cancer, inferred from his observations. The early blastocyst during its development has two distinct cell groups: the inner cell mass, which gives rise to the embryo, and an outer circle of trophoblastic cells, which enable implantation of the embryo into the uterus and subsequent formation of placenta (Fig. 1

Who reads Cancer Stem Cells : Identification and Targets?

Author

Sharmila A. Bapat, Pearl S. Huang

Publisher

Wiley-Interscience

Published

2008

Language

EN

ISBN

9780470122013

Category

nonfiction

Subjects

Science, Chemistry, Social Science